Faculty of Veterinary Medicine University of Zagreb
Abstract
Diabetology and rheumatology have much in common, including many biochemical features. Diabetic cases suffer excessively from common musculoskeletal conditions. The present study aimed to explore the association between the caffeic acid phenethyl ester (CAPE) treatment and the standard parameters of diabetic and rheumatologic controls. Serum anti-streptolysin-O (ASO), C-reactive protein (CRP), rheumatoid factor (RF) titers and glucose (GLU), cholesterol (CHOL), triglyceride (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), sodium (Na), potassium (K), chloride (Cl), calcium (Ca), phosphorus (P), uric acid (UA), iron (Fe), iron-binding capacity (IBC), total iron-binding capacity (TIBC) and superoxide dismutase (SOD) levels were measured in 22 female Wistar-Albino rats. The animals were divided into three groups: group 1: non-diabetic rats as control; group 2: streptozotocin (STZ)-induced, untreated diabetic rats; and group 3: STZ-induced, CAPE-treated diabetic rats. Levels of GLU were increased in group 2. ASO values were decreased in group 3. TG and VLDL levels were increased in group 3 compared with the group 1. Higher UA levels were detected in group 3 compared with group 2. The levels of Fe and TIBC were decreased in group 3. The results of the present study indicate the reducing effect of CAPE on the serum levels of diabetic and rheumatologic parameters in diabetic rats.Dijabetologija i reumatologija imaju mnoge sličnosti, uključujući biokemijske procese. Oboljeli od dijabetesa pate od teških stanja mišićno-koštanog sustava. U ovom radu istražena je povezanost između liječenja fenetil esterom kavene kiseline i standardnih pokazatelja koji se kontroliraju pri dijabetičnim i reumatoidnim bolestima. Kod 22 Wistar-Albino štakorice mjereni su: serumski anti-streptolizin-O (ASO), C-reaktivni protein (CRP), titar reumatoidnog faktora (RF), zatim razina glukoze (GLU), kolesterola (CHOL), triglicerida (TG), lipoproteina visoke gustoće (HDL), lipoproteina vrlo niske gustoće (VLDL), alkalne fosfataze (ALP), gamaglutamil transferaze (GGT), natrija (Na), kalija (K), klorida (Cl), kalcija (Ca), fosfora (P), mokraćne kiseline (UA), željeza (Fe), kapaciteta vezanja željeza (IBC), ukupnog kapaciteta vezanja željeza (TIBC) i superoksid dismutaze (SOD). Životinje su bile podijeljene u tri skupine: 1. štakorice bez dijabetesa (kontrolna skupina), 2. neliječene štakorice s dijabetesom izazvanim streptozotocinom (STZ) i 3. štakorice sa streptozotocin (STZ) - izazvanim dijabetesom liječenim fenetil esterom kavene kiseline. Razine GLU bile su povećane u skupini 2. ASO vrijednosti bile su snižene u skupini 3. Razine TG i VLDL bile su povišene u skupini 3 u usporedbi s razinama u skupini 1. Više razine UA utvrđene su u skupini 3 u usporedbi sa skupinom 2. Razine Fe i TIBC bile su snižene u skupini 3. Rezultati pokazuju reducirajuće učinke fenetil estera kavene kiseline na razinu dijabetičnih i reumatoloških pokazatelja u serumu štakorica sa šećernom bolešću izazvanom streptozotocinom
