Sestre Milosrdnice University hospital and Institute of Clinical Medical Research
Abstract
Rosacea is a common chronic inflammatory cutaneous disease of unknown etiology, characterized by remissions and exacerbations, presenting with centrofacial erythema and telangiectasias. It affects mainly adults around the age of 30 years and classically predominates in females. The pathophysiology of rosacea has not yet been fully understood. Risk factors are positive family history, very light skin phototype, sun exposure and consumption of spicy food or alcohol. Recently, there has been some evidence that some drugs or vitamins could be potential factors that can aggravate rosacea or induce rosacea-like symptoms. In this context, we present a 53-year-old female developing rosacea-like dermatitis due to a fixed combination of isoniazid and pyridoxine, which she was receiving along with rifampicin for the treatment of pulmonary tuberculosis.Rosacea je kronična upalna bolest kože nepoznate etiologije, obilježena remisijama i egzacerbacijama te kliničkom slikom centrofacijalnog eritema i pojavom teleangiektazija. Javlja se u odrasloj dobi, pretežito u 30-tim godinama, nešto češće u žena. Patofiziologija rosaceje još uvijek nije do kraja razjašnjena. Čimbenici rizika za pojavu bolesti su pozitivna obiteljska anamneza, svijetli fototip kože, izlaganje sunčevoj svjetlosti te konzumacija alkohola, kofeina, toplih napitaka i začinjene hrane. Međutim, neka istraživanja ukazuju na to da određeni lijekovi i vitamini također mogu biti provocirajući čimbenici u nastanku rozaceje ili pogoršanju već postojeće bolesti. Predstavljamo 53-godišnju bolesnicu u koje se razvio rosaceiformni dermatitis nakon započinjanja terapije fiksnom kombinacijom izoniazida i piridoksina (Eutizon®B6) i rifampicina (Rimactan®) u sklopu liječenja tuberkuloze
