Faculty of Veterinary Medicine University of Zagreb
Abstract
The objective of the present study was to investigate the effect of ofloxacin (10 mg/kg) on the pharmacokinetics of meloxicam (0.5 mg/kg) in goats, when administered concurrently by intravenous route. Meloxicam concentration in plasma was measured using HPLC assay. The pharmacokinetics of meloxicam were best described by the two-compartment open model. Following concurrent administration of meloxicam and ofloxacin, the mean plasma level of meloxicam was only found to be significantly higher (P<0.05) at 15 min compared to its alone administration. Statistical analysis of data revealed that there were no statistically significant differences in PK parameters between the two treatments, except K21. Therefore, the results of the present study suggest that concurrent administration of ofl oxacin and meloxicam in goats does not require any adjustment in dosage regimens. Based on PK determinants, meloxicam may be administered by i.v. route at 0.86 and 0.65 mg/kg, as loading and maintenance doses respectively, and is to be repeated at 8 h intervals.Istražen je učinak ofloksacina (10 mg/kg) na farmakokinetiku meloksikama (0,5 mg/kg) u koza pod uvjetima istodobne intravenske primjene. Koncentracija meloksikama u plazmi utvrđena je visokotlačnom tekućinskom kromatografijom. Kao najbolji model za opis njegove farmakokinetike korišten je otvoreni model s dvama odjeljcima. Istodobnom primjenom meloksikama i ofloksacina, srednja razina meloksikama u plazmi bila je statistički značajno viša (P<0,05) samo 15 minuta u usporedbi s primjenom samog meloksikama. Statistička analiza podataka pokazala je da između dva načina primjene ne postoje značajne razlike farmakokinetičkih pokazatelja, osim za K21. Rezultati istraživanja pokazuju da kod koza doziranje ofloksacina i meloksikama prilikom njihove istovremene primjene ne treba mijenjati. Na temelju farmakokinetičkih pokazatelja, meloksikam se može primijeniti intravenski u početnoj dozi od 0,86 mg/kg, te u dozi za održavanje od 0,65 mg/ kg, uz ponavljanje u vremenskim razmacima od 8 sati
