The Influence of Surface Treatment by Hydrogenation on the Biocompatibility of Different Hydroxyapatite Materials
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Abstract
The influence of hydrogenation on the biocompatibility of different hydroxyapatite (HAP) materials was tested. Materials consisted of pure HAP, HAP substituted with manganese (Mn+2) and with magnesium (Mg+2) – all axially pressed and conventionally sintered for 2 h at 1200 °C; pure HAP isostatic pressed and sintered by a microwave technique for 15 min at temperature of 1200 °C. Biocompatibility was compared by enumeration of the number of osteoblast-like cells to the materials before and after hydrogenation. Obtained results show that the osteoblastic cells demonstrated a higher ability to attach to HAP if its surface was negatively charged. Hydrogenation altered the surface potential; HAP substituted with manganese – HAP(Mn) and with magnesium – HAP(Mg) demonstrated the highest ability to engineer the charge