Analysis of Conformational Preferences of Triazole Containing Carbopeptoids

Abstract

Acetonide protected furanose rings are stereochemically defined molecular scaffolds that impose certain rigidity to the oligomeric structures made from them. Linking with an amide provides open sites for the formation of intramolecular hydrogen bonds when incorporated in the larger molecules, while triazole linkers add conformational stability and rigidity. Herein we present the synthesis and spectroscopic studies of the furanose-based amide- and triazole-linked carbopeptoides