The Exocyclic Olefin Geometry Control via Ireland—Claisen Rearrangement: Stereoselective Total Syntheses of Barmumycin (V) and Limazepine E (VI)
- Publication date
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- Wiley
Abstract
The highly selective Ireland—Claisen rearrangement of seven-membered lactone-derived boron enolate generated in situ is the key step to synthesize the naturally occurring antitumor agents (V) and (VI)