Avenia, Nicola

Sperlongano, Pasquale

Scientific Open-access Literature Archive and Repository

The role of laparoscopy in pancreatic surgery is still controversial and must address the fol-lowing potential applications: a) staging of pancreatic cancer; b) palliation of pancreatic cancer; c)pancreatic resection for benign and malignant disease; d) pancreatic drainage procedures.Carcinoma of the pancreas is the fifth commonest cause of cancer death in the Western world.Its incidence is quite doubled in Europe among the last twenty years. In Italy 10-12 new cases peryear/100.000 inhabitants are recorded. In most of cases it is ductal adenocarcinoma. The diagno-sis carries a poor prognosis with a 5 year mortality rate of about 95-99%. Thus, the mortality rela-ted to this pathology is quite similar to its incidence. Surgery is the only therapeutical option ofpancreatic cancer. Nevertheless, radical surgery requires good technical skill and can cause compli-cations and operative mortality. Thus, it should be addressed to patients who can really benefit interms of survival and quality of life. Less than 20% of pancreatic cancers are resectable for curebecause of extrapancreatic involvement. In these case palliation should be provided.A correct preoperative staging is necessary to identify patients with potentially resectable disea-se and those unresectable. There is still some concern about the management of pancreatic cancerand clear guidelines are yet not available. Radical surgery should be avoided in patients with extra-pancreatic involvement, evidence of local vascular invasion (portal vein, superior mesenteric veinand artery, aorta and vena cava), metastatic disease(liver, peritoneum, lymphnodes), and in agedpatients.Up to few years ago, 65% of laparotomies performed in patients deemed resectable showedevidence of metastatic disease. Advances in dynamic spiral CT-scan decreased the number ofunnecessary laparotomies. Diagnostic accuracy of CT scan is 95% in detecting local involvement,nodal and hepatic metastases, vascular invasion. Sensitivity of the technique is about 67% in detec-ting lesions up to 15 mm, 95-100% for lesions bigger than 15 mm.As previously said, in the  diagnostic-therapeutic protocol videolaparoscopy (VLS) is addressedto: a) staging; b) radical surgery; c) palliation.StagingVLS provides further informations concerning the disease, allowing the evaluation of thetumour resectability and then a better treatment strategy, decreasing unnecessary laparotomies andcosts. VLS is indicated in cases of pancreatic mass deemed resectable or “doubtful” by CT-scan.VLS is not indicated in case of mass deemed unresectable by CT-scan.It has improved the resectability for pancreatic cancer from 35 to 87%, thus reducing the num-ber of unnecessary laparotomies and palliation. Nevertheless, it should be remarked that CT-scancan be diagnostic  in 75-80% of cases if performed by an experienced imager. The role of VLS inthe staging of pancreatic cancer goes from the simple research of hepatic, peritoneal or visceralmetastases, to the extended procedure of exploration of the lesser sac, hepatic hilum, duodenum,293G Chir Vol. 26 - n. 8/9  - pp. 293-294Agosto-Settembre 2005La laparoscopia ha un ruolo nel cancro del pancreas?P. SPERLONGANO, N. AVENIA1Seconda Università degli Studi di NapoliDipartimento di Scienze Anestesiologiche, Chirurgiche e delle EmergenzeV Divisione di Chirurgia Generale e Tecniche Chirurgiche Speciali(Direttore: Prof. U. Parmeggiani)1Università degli Studi di PerugiaChirurgia Endocrina del Collo e Tessuti molliCentro di Riferimento Regionale - Terni(Direttore: Prof. N. Avenia)© Copyright 2005, CIC  Edizioni Internazionali, Romaeditorialetransverse mesocolon, celiac and porto-mesenteric vessels. Direct laparoscopic visualization can becombined with intraoperative laparoscopic ultrasonography (LUS). This last procedure has showna positive predictive value of resectability of 91%, enabling the recognition of vascular and nodalinvasion and the detection of hepatic metastases smaller than 1 cm.Laparoscopy also enables the sample for peritoneal cytology.Laparoscopic pancreatic resectionLaparoscopic pancreatoduodenectomy (LPD) was first described by Gagner in 1992. There isconcern that the patient undergoing LPD receives a compromised cancer operation, because it isdifficult to avoid leaving a remnant of the uncinate process of pancreas on the superior mesente-ric vein or artery. The surgery has been prolonged to an average of 9 hours and post-operative stayshave averaged close to 3 weeks. The complication rate has been on the order of 50%. Ther is alsoan higher rate of conversion (up to 40-60%) with higher costs. Lastly, this procedure requires verygood laparoscopic technical skill and then should be performed by well trained surgeons.Although the role for LPD is limited, laparoscopic distal pancreatectomy (LDP) with an “enbloc” splenectomy as well as with preservation of the spleen may provide significant patient bene-fit. The procedure has been attempted for both benign and malignant pancreatic pathology (isletcell tumours, chronic pancreatitis, cystoadenomas). The surgical procedure “only” takes from threeto five hours and allows a faster post-operative stay (5-6 days) with a conversion rate of 25%. LDPshould be performed in cases of neuroendocrine tumour of the pancreatic body or tail. It hasshown fewer complications than simple enucleation. The surgical technique has also been impro-ved thanks to the use of the harmonic scalpel, RF vessel sealing system (Ligasure®) and endo-scopic linear stapler. Laparoscopic enucleation (LE) of pancreatic tumours should performed incase of solitary, small benign neuroendocrine tumour , sited on the anterior pancreatic surface.Such intervention appears suited even for the same lesions placed in the head and the uncinate pro-cess of the pancreas. In these cases, in fact, LDP would be excessive.Palliation80% of patients with pancreatic cancer are not resectable at the time of diagnosis. The surgicalalternative provides biliary and digestive decompression as well as pain reduction. If jaundice isassociated with digestive obstruction, the suggested therapeutical option is biliary stenting pluslaparoscopic gastroenterostomy (Braun). Laparoscopic gastroenterostomy (LGE) is astraigthforward procedure allowing good gastric drainage if performed at the lower part of the sto-mach (antecolic-sited, 8 cm of size). LGE shows less morbidity and mortality, decreased post-ope-rative stay and costs and a better quality of life for patients than open gastroenterostomy.Laparoscopic pancreatic surgery represents a relatively new surgical domain with great poten-tial. Advanced laparoscopic skill and correct staging of the disease are necessary both to avoidunnecessary extensive surgery or perform laparoscopic resection.The better results in terms of complications and survival have been obtained with laparoscopicdistal pancreatic resection but not with pancreatoduodenectomy. Laparoscopic gastroenterostomyis technically feasible and a straigthforward means of palliating obstruction.Bibliografia1. Pisters PW, Lee JE, Vauthey JN, Charsnangavej C, Evans DB. Laparoscopy in the staging of pancreatic cancer Br JSurg 2001; 88: 325.2. Park AE, Heniford BT. Therapeutic laparoscopic of the pancreas. Ann Surg 2002; 236(2), 149.3. Iachida S, Fukushima N, Sakamoto M , Matsuno Y, Kosuge T, Hirohashi S. Implication of peritoneal washing cytologyin patients with potentialli resectable pancreatic cancer. Br J Surg 2002; 89, 573.4. Merchant NB. Conlon KC. Laparoscopic evaluation in pancreatic cancer Sem in Surg Oncol1998; 19:155.5. Gagner M, Pomp AJ. Laparoscopic pancreatic resection: is it wortwile? Gastrointestinal Surg 1997; 1:20.6. Cuschieri A, Jakiowicz JJ. Laparoscopic pancreatic resection. Semin Laparoscopic Surg 1998; 5,168.P. Sperlongano e Coll.294

La laparoscopia ha un ruolo nel cancro del pancreas?

http://eprints.bice.rm.cnr.it/7430/1/Paper_2.pdf

La laparoscopia ha un ruolo nel cancro del pancreas?

Abstract

Similar works

Full text

Available Versions

Scientific Open-access Literature Archive and Repository