Paget breast disease is a kind of intraductal carcinoma that through an intracanalicular diffusion invades the basal epidermical layer,reaching the areola and nipple, producing a typical erythematous desquamative
eczematous-like lesion. This neoplasia can remain undetected
for a long time and inadequately treated as a dermatological affection. Synchronous or metachronous lesions are very uncommon. Surgical choice is conditioned by the presence of a tumor below the epidermical lesion, by its dimensions, and by the possible lymph node involvement. Surgical therapy can be radical or conservative.
From our experience we think that lesion biopsy is always necessary to formulate a correct diagnosis and to schedule an appropriate therapeutic approach. In our case, a biopsy was performed first, then on the basis of the frozen section analysis a radical mastectomy with axillary
third level lymph nodes dissection, because of the large dimensions of thelesion and the previous history of a methachronous lesio
