Amedei, A.

Bacciottini, L.

Bartolini, E.

Brandi, M.L.

Cioppi, F.

Croppi, E.

Masi, L.

Pampaloni, B.

Tanini, A.

Tognarini, I.

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EVALUATION OF NUTRITIONAL HABITS IN STONE FORMINGHYPERCALCIURIC PATIENTSB. Pampaloni, E. Croppi, F. Cioppi, L. Bacciottini, E. Bartolini, A. Tanini, I. Tognarini, A. Amedei, L. Masi, M.L. BrandiDepartment of Internal Medicine, University of Florence, Florence, ItalyCalcic Nephrolithiasis (NC) is a common clinical disorder that involves 1 to 5% of the population, it has aconsiderable hereditary component and may be linked to several metabolic disorders. Its multifactorialpathogenesis share both genetic and nutritional factors. An excessive excretion of calcium (hypercalci-uria) is the major physiopathological mechanism of NC and is frequently observed in osteoporotic pa-tients, as result of either drug administration (calcium, vitamin D) or high bone turnover. A common patho-genetic mechanism of all such metabolic disorders may involve chronically maintained metabolic acido-sis, which determines bone loss and renal loss of calcium, due to both the buffer action carried out by theskeleton against acid radicals and as well as an increase in osteoclast-mediated bone resorption. A re-cent study has shown that, in the case of NC, a calcium deficient diet will not provide the hypotheticalbeneficial effects that a normocalcic, hypoproteic, hyposodic diet will (Borghi L. et al., 2002). Moreover, ithas been observed that a calcium nutritional deficiency, together with an excessive protein intake, candetermine a mineral mobilisation from bone thus causing an osteopenic or osteoporotic status. To betterevaluate the nutritional habits of hypercalciuric patients, a food frequency questionnaire was distributed to54 patients, age 49.5±15.7 y (range 15-81 y) recruited from a clinical survey. The results of the studyshow that the subjects calcium intake is less than 80% of the recommended daily intake and the proteinintake reaches up to 15% of their daily caloric intake. In our sample Na intake is 1656.7±407.9 mg/die forwomen and 1615±313.5 mg/die for men, the acid ossalic values are 185.7±112.8 mg/die for women and268.6±230.4 mg/die for men. Those values are higher than those recommended in an adequately bal-anced diet in terms of normal calcium content, low amounts of sodium chloride and ossalic acid and lowanimal protein content (a 2500 kcal diet contain 1150 mg/die Na and 200 mg/die ossalic acid).228 Clinical Cases in Mineral and Bone Metabolism 2005; 2(3): 185-252BSTR CT (V Congresso CCMBM)  18/11/2005  15.59  Pagina 228FOR REVIEWONLY© CIC EDIZIONI INTERNAZIONALI

Evalutation of nutritional habits in stone forming hypercalciuric patients

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Evalutation of nutritional habits in stone forming hypercalciuric patients

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