'American Association for the Advancement of Science (AAAS)'
Abstract
The goa-1 gene encoding the alpha subunit of the heterotrimeric guanosine triphosphatebinding protein (G protein) G_o. from Caenorhabditis elegans is expressed in most neurons, and in the muscles involved in egg laying and male mating. Reduction-of-function mutations in goa-1 caused a variety of behavioral defects including hyperactive movement, premature egg laying, and male impotence. Expression of the activated G_o alpha subunit
(Gα_o) in transgenic nematodes resulted in lethargic movement, delayed egg laying, and reduced mating efficiency. Induced expression of activated Gα_o in adults was sufficient to cause these phenotypes, indicating that Gα_o mediates behavior through its role in neuronal function and the functioning of specialized muscles