'American Society for Biochemistry & Molecular Biology (ASBMB)'
Abstract
A condition in which a synthesis of protein-like material occurs, was
first arranged in 1886 by Danilewski (1) who observed the formation of a
precipitate when stomach extract was added to a concentrated solution
of the products of peptic hydrolysis. He considered the causative agent
to be an enzyme, because precipitation did not occur if the stomach extract
had been previously heated to 100°C. This result was confirmed in 1895 by
Okunew. Both Danilewski and Okunew concluded that the reaction involved
synthesis of the products of protein decomposition into a more composite
molecule approaching in complexity a native protein