Hubl, D.

Schiebler, S.

Schimmelmann, B.

Schultze-Lutter, F.

Stegmayer, K.

Strik, W.

Tolev, A.

Walther, S.

Bern Open Repository and Information System (BORIS)

source: https://doi.org/10.48350/47572 | downloaded: 17.2.2023Results: Age and deviant-type interacted, with significant increase ofMMN amplitudes to duration- and phoneme-deviants with increase ofage. Neuropsychological variables correlated with MMN.Conclusion: The establishment of a developmental database ofMMN is crucial as a reference for high-risk populations. MMNs toduration and phonetic deviants might be influenced notably byneurodevelopment.Policy of full disclosure: None.P-11-008Comparison of two video-based assessments for abnormal motorbehavior in adolescents at risk for psychosisS. Schiebler (University Hospital Bern Psychiatry, Bern,Switzerland), A. Tolev, K. Stegmayer, D. Hubl, W. Strik,F. Schultze-Lutter, B. Schimmelmann, S. WaltherObjective: Motor signs are frequent in schizophrenia (Walther &Strik, 2012). In addition, abnormal movements were reported insubjects at high risk for developing psychosis (Mittal et al., 2011).Video based ratings have previously applied a variety of instrumentsto study abnormal movements in children and adolescents at risk or inschizophrenia patients (Walker et al., 1994; Gharabawi et al., 2005).In elderly schizophrenia patients different dyskinesia rating scalesdemonstrated strong agreement in real-life assessments (Dean et al.,2004). However, the agreement of ratings from video-taped interviewsituations and ratings from video-taped structured assessments isunknown. Furthermore, it still remains unclear whether this applies toyounger subjects at risk for psychosis.Methods: We investigated 21videos of adolescents that underwentscreening for psychosis at the center for the early detection andintervention in psychoses, University Hospital of Psychiatry Bern,between 2011 and 2012. Video recordings were available for aninterview situation when subjects were seated at a table. In addition,the examination procedure of the Abnormal Involuntary MovementScale (AIMS) was recorded on video for each participant. Twotrained raters separately and blinded to the diagnosis assessed thevideos regarding the severity of movement disorders using the AIMSand the Dyskinesia Identification System: Condensed User Scale(DISCUS). The DISCUS is empirically derived and contains 15 itemsthat are rated on a 0–4 (absent to severe) scale (Sprague, Kalachnik,et al., 1984a; Kalachnik, et al., 1988 et 1993). Bivariate correlationsbetween AIMS and DISCUS scores were calculated.Results: The analyses are still ongoing. Results will be presented atthe meeting.Conclusion: We expect moderate correlation values with higherscores in the structured examination (AIMS).Policy of full disclosure: None.P-11-009Brain activation during self-reflection in ultra-high riskfor psychosisE. Opmee (University Medial Center Neuroimaging Center,Groningen, Netherlands), E. Liemburg, J. van der Velde, R. Nieboer,L. Wunderink, A. AlemanObjective: Disturbances in the basic sense of the self have beenassociated with vulnerability for psychosis. The cortical midlinestructures (CMS) of the brain, the inferior frontal gyrus (IFG), andinferior parietal lobule (IPL) play an important role in self-reflectiveprocessing. Previously, our group has reported abnormal activationsin these regions in patients with schizophrenia (van der Meer et al.,2012) and in people with high psychosis proneness (Modinos et al.,2011). The aim of the current study was to investigate brain activationduring self-reflection in a sample with an ultra-high risk (UHR) forpsychosis.Methods: Twelve UHR-subjects were included in addition to twelveage-, sex- and education-matched healthy controls (HC). All partici-pants performed a self-reflection task during functional MRIscanning. The task comprised a self-reflection, other-reflection andsemantic (baseline) condition. Both reflection conditions containedpositive and negative related traits.Results: UHR-subjects attributed more negative (U = 26, p\ .05)and less positive traits (U = 14.5, p\ .05) to themselves than HC.There were no differences for other-related traits. Functional MRIanalyses showed that both groups robustly activated the CMS duringreflection of the traits to self and others compared to judging semanticbaseline sentences. Only during reflection of positive traits to the self,between group differences were present: UHR-subjects showed moreactivation in the right IFG and left IPL (p\ .001 unc.).Conclusion: To conclude, UHR-subjects attributed less positive traitsto themselves, which on a neural level was reflected by more acti-vation in areas relevant for self-reflective processing. This couldimply a less efficient processing of positive traits and might beassociated with low self-esteem and depression symptoms, whichhave both been described in UHR-individuals.Policy of full disclosure: None.P-11-010Formal thought disorder in high-risk for psychosis individualsM. Skuhareuskaya (RSPC for Mental Health psychiatric, Minsk,Belarus), Y. Fralova, N. Danilevich, E. KudinaObjective: Formal Thought Disorder (FTD) has been considered as acentral characteristic of schizophrenia for many years. The presenceof subtle forms FTD was revealed in first-degree relatives of patientswith schizophrenia. FTD in combination with other high-risk criteriamay be a valuable predictor of subsequent development of psychosis.Methods: The presence of FTD in clinical high risk individuals wasassessed with methods of experimental pathopsychology (L.Vygot-sky, B.Zeigarnik, Yu.F.Polyakov and others). Zeigarnik considersthinking in the framework of activity theory (A.N.Leontiev). There-after, it is necessary to distinguish its dynamic, operational andmotivational disturbances. The last two ones are typical for schizo-phrenia. Such disturbances are observed also in remission. The usedinstruments are ‘classifications of objects and words’, ‘exclusion ofobjects’, ‘interpretation of metaphors’, ‘mediated memorization’ and‘pictograms’. All these instruments are widely used as a basic andwell validated method of pathopsychological assessment in Russian-speaking countries. We assessed FTD in putatively late prodromalindividuals (n = 28), characterized by attenuated or brief psychoticsymptoms, and in early prodromal individuals (n = 41), mainlycharacterized by the presence of basic symptoms (COPER criteria bySchizophrenia Proneness Instrument).Results: Distortion of intellectual operations (loose associations) wasrevealed in 91 % of clinical high risk individuals. There were notsignificant differences in number of distortions between late and earlyprodromal individuals. Late prodromal state was associated withhigher number of emotionally cold images in pictograms, the pres-ence of diversity of opinion, philosophizing (‘disorders ofmotivational component of thinking’). In high-risk individuals withsubsequent development of psychosis were revealed dynamics ofFTD after the first psychosis with increasing numbers of distortions ofintellectual operations, empty and emotionally cold images in picto-grams and difficulties in abstract thinking.S104 Eur Arch Psychiatry Clin Neurosci (2013) 263 (Suppl 1):S7–S111123

German

Comparison of two video-based assessments for abnormal motor behavior in adolescents at risk for psychosis

Comparison of two video-based assessments for abnormal motor behavior in adolescents at risk for psychosis

Abstract

Similar works

Full text

Available Versions

Bern Open Repository and Information System (BORIS)