Persistent decline in estimated but not measured glomerular filtration rate on tenofovir may reflect tubular rather than glomerular toxicity

Abeling, Nico G G M; Brinkman, Kees; Furrer, Hansjakob; Fux, Christoph A; Garcia, Evian Fernandez; Hoek, Frans J; Krediet, Ray T; Prepare Study Group,; Reiss, Peter; Vrouenraets, Saskia M E; Wit, Ferdinand W N M

Persistent decline in estimated but not measured glomerular filtration rate on tenofovir may reflect tubular rather than glomerular toxicity

Authors: Nico G G M Abeling
Kees Brinkman
Hansjakob Furrer
Christoph A Fux
Evian Fernandez Garcia
Frans J Hoek
Ray T Krediet
Prepare Study Group,
Peter Reiss
Saskia M E Vrouenraets
Ferdinand W N M Wit
Publication date: 1 January 2011
Publisher: 'Ovid Technologies (Wolters Kluwer Health)'
Doi

Abstract

Tenofovir disoproxil fumarate (TDF) has been associated with proximal renal tubulopathy and reduction in estimated glomerular filtration rate (eGFR), without accounting for the tubular secretion of creatinine

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