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Optimization of the Analytical Method for Dioxin-Like PCBs in Low Volume Samples of Human Serum of Patients Facing Fertility Problems

Abstract

Several studies indicate that human semen quality and fertility have declined over the last decades. According to the estimation of World Health Organization about 8% of couples at the global level experience some forms of infertility problem during their reproductive lives. This percentage means that 50 to 80 million people have problems with fertility. Several lifestyle-related (obesity, smoking) and environmental (exposure to traffic exhaust fumes, dioxins, combustion products) factors appear to negatively affect human fertility, emphasizing the importance of environmental/lifestyle impacts throughout the life course.Support for this work was provided by: Ministry of Education and Science (Spain) (CTQ2008-05520 project); Valencian Community Government (Spain) (PROMETEO/2009/043/FEDER and ACOMP2011/224 projects); Chair Human Fertility of University of Alicante

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