Melanoma is a very aggressive form of skin cancer whose incidence has constantly grown in the last 50 years. To increase the survival rate, an early diagnosis followed by a prompt excision is crucial and requires an accurate and periodic analysis of the patient's melanocytic lesions. We have developed an hardware and software solution named Mole Mapper to assist the dermatologists during the diagnostic process. The goal is to increase the accuracy of the diagnosis, accelerating the entire process at the same time. This is achieved through an automated analysis of the dermatoscopic images which computes and highlights the proper information to the dermatologist. In this thesis we present the 3 main algorithms that have been implemented into the Mole Mapper:
A robust segmentation of the melanocytic lesion, which is the starting point for any other image processing algorithm and which allows the extraction of useful information about the lesion's shape and size. It outperforms the speed and quality of other state-of-the-art methods, with a precision that meets a Senior Dermatologist's standard and an execution time that allows for real-time video processing;
A virtual shaving algorithm, which increases the precision and robustness of the other computer vision algorithms and provides the dermatologist with a hair-free image to be used during the evaluation process. It matches the quality of state-of-the-art methods but requires only a fraction of the computational time, allowing for computation on a mobile device in a time-frame compatible with an interactive GUI;
A registration algorithm through which to study the evolution of the lesion over time, highlighting any unexpected anomalies and variations. Since a standard approach to this problem has not yet been proposed, we define the scope and constraints of the problem; we analyze the results and issues of standard registration techniques; and finally, we propose an algorithm with a speed compatible with Mole Mapper's constraints and with an accuracy comparable to the registration performed by a human operator
