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Application of Chemical Modified Electrode in Drug Analysis
Authors
Anthony Bretaudeau (116576)
Claude Rispe (36471)
+7 more
Daciana Papura (322392)
Denis Tagu (36472)
Fabrice Legeai (65391)
François Delmotte (3314697)
Gaël Le Trionnaire (36468)
Julie Jaquiéry (443570)
Sylvie Hudaverdian (572383)
Publication date
6 June 2014
Publisher
化學系
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Abstract
本研究利用全氟磺酸聚合物/含釕黃綠石氧化物(Nafion/Ru-oxide Pyrochlore)化學修飾電極偵測茶鹼(Theophylline)及兩種抗生素磺胺二 甲嘧啶(Sulfamethazine, SMZ), 磺胺二甲氧嘧啶(Sulfadimethoxine, SDM), 並對其在藥劑, 食品中的真實樣品做偵測. 茶鹼為強心, 利尿 劑, 亦有支氣管擴張, 冠動脈擴張, 平滑肌鬆弛功能. 以往皆是以層析方 法分析茶鹼, 本研究以化學修飾電極, 配合方波伏安法, 藉由修飾電極裡 的Ru-oxidePyrochlore對茶鹼的催化性, 以達到微量偵測的目的. 最佳的 方波條件為: 振幅30mV, 頻率45Hz, 預濃縮電位0V, 預濃縮時間15秒, 其 線性範圍為2至100uM, 偵測極限可達0.103uM(S/N=3), 再現性方面, 10uM 標準品連續偵測12次C.V.值1.34%, 並對紅茶, 綠茶等樣品進行標準品添 加校正曲線實驗, 其現性相關係數高達0.999. 本研究利用上述催化電 極, 進行對磺胺二甲嘧啶(SMZ)及磺胺二甲氧嘧啶(SDM)的偵測.磺胺劑為 常加在豬, 牛等家畜的飼料中以增加對疾病的抵抗能力的抗生素. 本研究 亦利用方波伏安法進行偵測. 偵測線性範圍分別為2-30uM, 2-25uM, 偵測 極限可達0.118uM, 0.129uM(S/N=3). 再現性方面, 20uM的SMZ與SDM標準 品連續偵測12次C.V.值分別為2.21%, 1.26%. 在實際樣品的偵測方面, 我 們選用了豬肉和牛奶來作實際樣品的偵測, 由於豬肉, 牛奶中可能未含有 磺胺劑, 或含量可能少於本實驗方法之偵測極限, 故並未有訊號出現. 但 添加少量磺胺劑後, 就有電流訊號產生, 且有很好的線性關係, 証明此電 極可應用於實際樣品的偵測
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