Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines

Abstract

International audienceA series of new 1-[di-(4-R-phenyl)-methylidenyl)]-[3]ferrocenophanes, where R = OH, NH2, NHAc, and the phenyl substitution is mixed or identical, are highly antiproliferative against MDA-MB-231 and PC-3 cancer cells, with IC50 values ranging from 0 05-5 6 mu M on MDA-M B-231 and 0 02-12 5 mu M on PC-