This paper presents flight results from the early harvest of the Spaceborne Autonomous Formation Flying Experiment (SAFE) conducted in the frame of the PRISMA mission. SAFE represents one of the first demonstrations in low Earth orbit of an advanced guidance, navigation and control system for dual-spacecraft formations. Innovative techniques based on differential GPS-based navigation and relative orbital elements control are validated and tuned in orbit to fulfill the typical requirements of future distributed scientific instruments for remote sensin