Effect of microgravity on MAPK signaling in cells of the Immune system

Abstract

Vector-averaged gravity resulted in: → Rapid activation of MAPK pathway in Jurkat T cells, but not in U937 cells → Tyrosine phosphorylation in non-stimulated U937 cells → Tyrosine dephosphorylation in PMA-stimulated U937 cells → Reduced nuclear translocation of p65 in Jurkat T cells, but not in U937 cells → Enhanced binding of phospho-histone H3 on chek-1, c-jun and fas-promotor sequences in Jurkat T cell