This work is aimed at assessing the capability of Ni-Ti(-Cu) interlayers, integrated in a bilayer design (tribological top layer/Ni-Ti(-Cu) layer/substrate), to improve the resistance against adhesion damage and the tribological performance of W-S-C self-lubricant coatings, when these bilayers are subjected to different sliding conditions. Interesting differences on adhesion and tribological performance are observed in relation to the grain size of the interlayer materia