High shear wet granulation is a particle design process used to increase the size of a primary powder material through the addition of liquid binder. This thesis focuses on the multi-scale nature of high-shear granulation in order to understand behavior changes due to coupled consolidation and coalescence as well as operational changes that occur during the scale up of horizontal ploughshare mixer granulators. The methodology relied on a micro-scale model for coalescence, a meso-scale model to describe flow within the granulator and a macro-scale population balance to describe the whole system
