Global activity in mergers and acquisitions (M&As) has weakened during the past year and a half. With continued concerns about the recovery of the global economy, many large companies were reluctant to close mega-deals. Economic and political events, such as increased fiscal crises in Europe, slowing economic growth in the BRIC countries, and political gridlock in Washington, reduced confidence among many dealmakers. Despite companies’ record cash reserves, many were reluctant to execute new M&A deals. In this article, we discuss global M&A activity in 2011 and the first half of 2012. The article concludes with a discussion of factors for middle-market companies to consider in pursuing cross-border M&As