A method of compressor performance analysis under multiple working conditions is present based on the Time-weighted average (TWA). The main operation parameters can be obtained based the estimate of the working conditions and times of compressors. Then the comprehensive analysis method can be used to get the overall performance of compressor. The performance of a basic centrifugal compressor was simulation by CFD method in this paper. The overall performance of the centrifugal compressor is calculated under different working conditions. The TWA analysis method can be used as a tool to evaluate the overall performance of compressor. And it can also be used during the design phase to improve the performance of compressor fundamentally