Chemical Synthesis of Bacterial Siderophores and Applications in Pathogen Detection

Abstract

Bacterial siderophores are a class of small organic compounds that are produced endogenously by bacteria to chelate essential ferric iron from their surroundings. Because the bioavailability of ferric iron is extremely low is physiological pH, the host of a parasitic infection can be a poor source of soluble Fe3+. Consequently, bacteria rely upon siderophore transport systems to efficiently scavenge the nutrient. Nearly every bacteria

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