NPP OMPS was launched on October 28, 2011. It opened its nadir aperture door on June 24, 2002, beginning its Earth observing mission. OMPS is a push-broom instrument suite with a 110-degree cross-track Field of View (FOV) telescope. Sensor on-orbit calibrations include solar, lamp, and dark measurements. The onboard Calibrators Light-emitting diode (LED) provides linearity calibration and Reflective solar diffuser maintains calibration stability through periodic solar observations. In this paper, we present early results from OMPS operational instruments Nadir Profiler and Nadir total column on-orbit calibration and characterization. Examples of the sensor’s short-term and limited long-term responses will be provided to illustrate the sensors on-orbit stability. These early results indicate that the on-orbit performance has been in good agreement with the predication determined from prelaunch measurements