Creosote bush scrub vegetation typically contains high diversity of native annual plants relative to shrubs, cacti, perennial herbaceous species, or other plant life forms. This vegetation type is also very susceptible to exotic, invasive annual plants, which promote fire by changing fuel properties. The impact of fire on most perennial species is severe but the impact on native annual plants is not well understood. We measured annual species composition in five sites that each contained paired burned and unburned stands in the western Colorado Desert, California. The burned stands at each site ranged in time since fire from 3 to 29 years ago. Annual plant cover, species richness, and soil chemical and physical properties were compared in the paired burned and unburned reference stands. Differences between paired stands at the time of each fire are assumed negligible since shrub cover across fuel breaks did not differ prior to each fire based on aerial photographs. Fires elevated soil pH but otherwise had little effect on other soil properties. In recently burned stands, invasive annual grass abundance increased while native annual plant cover and species richness decreased. However, in older burned stands, annual plant composition did not always differ between paired stands because invasive annual plant abundance was very high in both stands. Thus, while fires can have long-lasting negative impacts to perennial components of creosote bush scrub, invasive species can displace native annual plants regardless of whether or not a site burns, although fire disturbance appears to accelerate invasive plant dominance