Synthesis of Molecularly Imprinted Polymers for Protein Detection and Sample Depletion

Abstract

Molecular Imprint Polymers (MIPs) constitute a unique class of chemically-synthesized antigen recognition materials. As microparticles and nanoparticles, they can act as synthetic antibodies with numerous potential applications. We will develop protocols for the rapid generation of albumin-binding MIPs, characterize the affinity and specificity of the resulting particles, and investigate their application towards serum depletion for proteomics