The era of the internet-of-things (IOT) is expanding the utilization of mobile and cloud computing to a global scale. The enormous data transport places a huge design overhead in building low-cost, low-power, low-error-rate high-speed data links. This thesis provides a system-level overview of the design, simulation, and measurement of high-speed digital applications in the context of signal integrity. Examples are provided to demonstrate the design approach and trade-offs made to arrive at the results. Modeling and simulation methodologies for high-speed interconnect are discussed and studied, using both conformal mapping and the variational method in closed-form solutions, with examples provided to study the frequency-dependent channel effects in high-speed digital systems. Detailed processes along with examples are presented at the end to illustrate some real-world issues many engineers will face when characterizing and measuring high-speed data links