CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Antiproliferative and genotoxic activities in L929 and HeLa cell lines, mutagenic effects in Salmonella strains of novel benzoxazole derivatives
Authors
Kayhan Bolelli
Tuğba Ertan-Bolelli
+3 more
Egemen Foto
Fatma Zilifdar
Emine Öksüzoğlu
Publication date
1 January 2016
Publisher
Colegio de Farmaceuticos de la Provincia de Buenos Aires
Abstract
Some novel fused heterocyclic compounds of 2,5-disubstituted-benzoxazole derivatives, which were previously synthesized by our group, were investigated for their mutagenic properties on Salmonella typhimurium TA 98 and TA 100 strains, cytotoxic activity in L929 and HeLa cell lines by Sulforhodamine B (SRB) cytotoxicity test, and genotoxic potentials in the comet assay. By using Ames/Salmonella assay in the presence of S9 fraction, B22 (5-nitro-2-(p-nitrobenzyl)benzoxazole) was found to be mutagenic in both S. typhimurium TA98 and TA100 strains at all tested doses. IC50 values which were evaluated by SRB cytotoxicity assay revealed that B11 (2-(p-nitrobenzyl)benzoxazole) (IC50 = 99.16 µM) was the most anti-proliferative compound on HeLa cancer cells. Compounds were also tested for their genotoxicity by using comet assay, and it was found that all the compounds had DNA-damaging genotoxic activity on HeLa cells. The comet assay results showed that B11 produced DNA damage at lower concentrations than the other compounds tested on HeLa cancer cells. The results obtained from all the tests suggest that B11 could be a good candidate as a new anticancer agent. © 2016, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved
Similar works
Full text
Available Versions
Aksaray University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:acikerisim.aksaray.edu.tr:...
Last time updated on 05/12/2019