High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic,
diastolic, pulse pressure) to date in over one million people of European ancestry. We
identify 535 novel blood pressure loci that not only offer new biological insights into blood
pressure regulation but also reveal shared genetic architecture between blood pressure and
lifestyle exposures. Our findings identify new biological pathways for blood pressure
regulation with potential for improved cardiovascular disease prevention in the future