Studying the implications of the bilateral agreements between the Republic of Panama and the People’s Republic of China of 2017 allows us to understand the economic and political effects of Chinese diplomacy on international cooperation, economic development, and soft power under the principles of trust and mutual benefit. The objective is to theorise the possible risks of the various aspects of these agreements; expand or modify their terms, ideally, if desirable; promote all sectors’ participation; and collect scientific evidence to make the agreements easier for decision-makers to evaluate. Maintaining complex, interdependent relationships with different spheres of power requires prioritising national interests and adapting them to the new global reality of the COVID-19 pandemic, which requires adjusting agreements on grounds other than the Belt and Road’s specific objectives