Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 35 million people globally, with more than 1 million deaths recorded by WHO as of Oct 12, 2020. As a second wave of COVID-19 affects Europe, and with winter approaching, we need clear communication about the risks posed by COVID-19 and effective strategies to combat them. Here, we share our view of the current evidence-based consensus on COVID-19

Alwan, Nisreen A

Ashworth, Simon

Beale, Rupert

Bhadelia, Nahid

Bogaert, Debby

Burgess, Rochelle Ann

Dowd, Jennifer

Eckerle, Isabella

Goldman, Lynn R

Greenhalgh, Trisha

Gurdasani, Deepti

Hamdy, Adam

Hanage, William P

Hodcroft, Emma B

Hyde, Zoë

Kellam, Paul

Kelly-Irving, Michelle

Krammer, Florian

Lipsitch, Marc

McKee, Martin

McNally, Alan

Nouri, Ali

Pimenta, Dominic

Priesemann, Viola

Rutter, Harry

Silver, Joshua

Sridhar, Devi

Swanton, Charles

Walensky, Rochelle P

Yamey, Gavin

Ziauddeen, Hisham

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 35 million people glob ally, with more than 1 million deaths recorded by WHO as of Oct 12, 2020. As a second wave of COVID-19 affects Europe, and with winter approaching, we need clear communication about the risks posed by COVID-19 and effective strategies to combat them. Here, we share our view of the current evidence-based consensus on COVID-19

Alwan, N.

Burgess, R.

Ashworth, S.

Beale, R.

Bhadelia, N.

Bogaert, D.

Dowd, J.

Eckerle, I.

Goldman, L.

Greenhalgh, T.

Gurdasani, D.

Hamdy, A.

Hanage, W.

Hodcroft, E.

Hyde, Z.

Kellam, P.

Kelly-Irving, M.

Krammer, F.

Lipsitch, M.

McNally, A.

McKee, M.

Nouri, A.

Pimenta, D.

Priesemann, V.

Rutter, H.

Silver, J.

Sridhar, D.

Swanton, C.

Walensky, R.

Yamey, G.

Ziauddeen, H.

MPG.PuRe

Scientific consensus on the COVID-19 pandemic: we need to act now

Utrecht University Repository

Alwan, NA

Burgess, RA

Ashworth, S

Beale, R

Bhadelia, N

Bogaert, D

Dowd, J

Eckerle, I

Goldman, LR

Greenhalgh, T

Gurdasani, D

Hamdy, A

Hanage, WP

Hodcroft, EB

Hyde, Z

Kellam, P

Kelly-Irving, M

Krammer, F

Lipsitch, M

McNally, A

McKee, M

Nouri, A

Pimenta, D

Priesemann, V

Rutter, H

Silver, J

Sridhar, D

Swanton, C

Walensky, RP

Yamey, G

Ziauddeen, H

UCL Discovery

  Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website.  Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.  CorrespondenceSubmissions should be made via our electronic submission system at http://ees.elsevier.com/thelancet/www.thelancet.com   Vol 396   October 31, 2020 e71Scientific consensus on the COVID-19 pandemic: we need to act nowSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 35 million people glob ally, with more than 1 million deaths recorded by WHO as of Oct 12, 2020. As a second wave of COVID-19 affects Europe, and with winter approaching, we need clear communication about the risks posed by COVID-19 and effective strategies to combat them. Here, we share our view of the current evidence-based consensus on COVID-19.SARS-CoV-2 spreads through con-tact (via larger droplets and aerosols), and longer-range transmission via aerosols, especially in conditions where ventilation is poor. Its high infectivity,1 combined with the suscep tibility of unexposed populations to a new virus, creates conditions for rapid community spread. The infection fatality rate of COVID-19 is several-fold higher than that of seasonal influenza,2 and infection can lead to persisting illness, including in young, previously healthy people (ie, long COVID).3 It is unclear how long protective immunity lasts,4 and, like other seasonal coronaviruses, SARS-CoV-2 is capable of re-infecting people who have already had the disease, but the frequency of re-infection is unknown.5 Transmission of the virus can be mitigated through physical distancing, use of face coverings, hand and respiratory hygiene, and by avoiding crowds and poorly ventilated spaces. Rapid testing, contact tracing, and isolation are also critical to controlling transmission. WHO has been advocating for these measures since early in the pandemic.In the initial phase of the pandemic, many countries instituted lockdowns (general population restrictions, including orders to stay at home and work from home) to slow the rapid spread of the virus. This was essential to reduce mortality,6,7 prevent health-care services from being overwhelmed, and buy time to set up pandemic response systems to suppress transmission following lockdown. Although lockdowns have been disruptive, substantially affecting mental and physical health, and harming the economy, these effects have often been worse in countries that were not able to use the time during and after lockdown to establish effective pandemic control systems. In the absence of adequate provisions to manage the pandemic and its societal impacts, these countries have faced continuing restrictions.This has understandably led to widespread demoralisation and diminishing trust. The arrival of a second wave and the realisation of the challenges ahead has led to renewed interest in a so-called herd immunity approach, which suggests allowing a large uncontrolled outbreak in the low-risk population while protecting the vulnerable. Proponents suggest this would lead to the development of infection-acquired population immunity in the low-risk population, which will eventually protect the vulnerable.This is a dangerous fallacy unsup-ported by scientific evidence.Any pandemic management strat-egy relying upon immunity from natural infections for COVID-19 is flawed. Uncontrolled transmission in younger people risks significant morbidity3 and mortality across the whole population. In addition to the human cost, this would impact the workforce as a whole and overwhelm the ability of health-care systems to provide acute and routine care. Furthermore, there is no evidence for lasting protective immunity to SARS-CoV-2 following natural infection,4 and the endemic transmission that would be the consequence of waning immunity would present a risk to vulnerable populations for the indefinite future. Such a strategy would not end the COVID-19 pandemic but result in recurrent epidemics, as was the case with numerous infectious diseases before the advent of vaccination. It would also place an unacceptable burden on the economy and health-care workers, many of whom have died from COVID-19 or experienced trauma as a result of having to practise disaster medicine. Additionally, we still do not understand who might suffer from long COVID.3 Defining who is vulnerable is complex, but even if we consider those at risk of severe illness, the proportion of vulnerable people constitute as much as 30% of the population in some regions.8 Prolonged isolation of large swathes of the population is practically impossible and highly unethical. Empirical evidence from many coun tries shows that it is not feasible to restrict uncontrolled outbreaks to particular sections of society. Such an approach also risks further exacerbating the socio-economic inequities and structural discriminations already laid bare by the pandemic. Special efforts to protect the most vulnerable are essential but must go hand-in-hand with multi-pronged population-level strategies.Once again, we face rapidly acceler-ating increase in COVID-19 cases across much of Europe, the USA, and many other countries across the world. It is critical to act decisively and urgently. Effective measures that suppress and control transmission need to be implemented widely, and they must be supported by financial and social programmes that encourage community responses and address the inequities that have been amplified by the pandemic. Continuing restrictions will probably be required in the short term, to reduce transmission and fix ineffective pandemic response systems, in order to prevent future lockdowns. The purpose of these restrictions is to effectively suppress SARS-CoV-2 infections to low levels Published Online October 14, 2020 https://doi.org/10.1016/ S0140-6736(20)32153-XFor the WHO COVID-19 dashboard see https://covid19.who.int/Correspondencee72 www.thelancet.com   Vol 396   October 31, 20201 Hao X, Cheng S, Wu D, Wu T, Lin X, Wang C. Reconstruction of the full transmission dynamics of COVID-19 in Wuhan. Nature 2020; 584: 420–24.2 Verity R, Okell LC, Dorigatti I, et al. Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis 2020; 20: 669–77.3 Nature. Long COVID: let patients help define long-lasting COVID symptoms. Nature 2020; 586: 170.4 Chen Y, Tong X, Li Y, et al. A comprehensive, longitudinal analysis of humoral responses specific to four recombinant antigens of SARS-CoV-2 in severe and non-severe COVID-19 patients. PLoS Pathog 2020; 16: e1008796.5 Parry J. COVID-19: Hong Kong scientists report first confirmed case of reinfection. BMJ 2020; 370: m3340.6 Flaxman S, Mishra S, Gandy A, et al. Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe. Nature 2020; 584: 257–61.7 Dehning J, Zierenberg J, Spitzner FP, et al. Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions. Science 2020; 369: eabb9789.8 Clark A, Jit M, Warren-Gash C, et al. Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study. Lancet Glob Health 2020; 8: e1003–17.Roche-Ventana, Ono Pharmaceutical, GlaxoSmithKline, Novartis, Celgene, Illumina, MSD, Sarah Canon Research Institute, Genentech, Bicycle Therapeutics, and Medicixi, outside the submitted work; personal fees and stock options from GRAIL and Achilles Therapeutics, outside the submitted work; and stock options from Epic Biosciences and Apogen Biotechnologies, outside the submitted work. GY directs the Center for Policy Impact in Global Health at Duke University, which has received grant funding from the Bill & Melinda Gates Foundation for policy research that includes policy analysis on COVID-19 control. All other authors declare no competing interests within the submitted work.Nisreen A Alwan, Rochelle Ann Burgess, Simon Ashworth, Rupert Beale, Nahid Bhadelia, Debby Bogaert, Jennifer Dowd, Isabella Eckerle, Lynn R Goldman, Trisha Greenhalgh, *Deepti Gurdasani, Adam Hamdy, William P Hanage, Emma B Hodcroft, Zoë Hyde, Paul Kellam, Michelle Kelly-Irving, Florian Krammer, Marc Lipsitch, Alan McNally, Martin McKee, Ali Nouri, Dominic Pimenta, Viola Priesemann, Harry Rutter, Joshua Silver, Devi Sridhar, Charles Swanton, Rochelle P Walensky, Gavin Yamey, Hisham Ziauddeend.gurdasani@qmul.ac.ukSignatories are listed in the appendix.University of Southampton, Southampton, UK (NAA); University College London, London, UK (RAB, CS); Imperial College Healthcare NHS Trust, London, UK (SA); Francis Crick Institute, London, UK (RB, CW); Boston University School of Medicine, Boston, MA, USA (NB); University of Edinburgh, Edinburgh, UK (DB, DS); University of Oxford, Oxford, UK (JD, TG, JS); Geneva Centre for Emerging Viral Diseases, Geneva, Switzerland (IE); George Washington University Milken Institute School of Public Health, Washington, DC, USA (LRG); Queen Mary University of London, London, UK (DG); Ligandal, San Francisco, CA, USA (AH); Harvard T. H. Chan School of Public Health, Boston, MA, USA (WPH, ML); Biozentrum, University of Basel, Basel, Switzerland (EBH); University of Western Australia, Perth, WA, Australia (ZH); Imperial College London, London, UK (PK); Inserm, Toulouse, France (MK-I); Icahn School of Medicine at Mount Sinai, New York City, NY, US (FK); University of Birmingham, Birmingham, UK (AM); London School of Hygiene & Tropical Medicine, London, UK (MM); IndieSAGE, London, UK (MM); Federation of American Scientists, Washington, DC, USA (AN); Healthcare Workers Foundation (HEROES), London, UK (DP); Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany (VP); University of Bath, Bath, UK (HR); Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (RPW); Duke University, Durham, NC, USA (GY); and University of Cambridge, Cambridge, UK (HZ)that allow rapid detection of localised outbreaks and rapid response through efficient and comprehensive find, test, trace, isolate, and support systems so life can return to near-normal without the need for generalised restrictions. Protecting our economies is inextricably tied to controlling COVID-19. We must protect our workforce and avoid long-term uncer-tainty.Japan, Vietnam, and New Zealand, to name a few countries, have shown that robust public health responses can control transmission, allowing life to return to near-normal, and there are many such success stories. The evidence is very clear: controlling community spread of COVID-19 is the best way to protect our societies and economies until safe and effective vaccines and therapeutics arrive within the coming months. We cannot afford distractions that undermine an effective response; it is essential that we act urgently based on the evidence.To support this call for action, sign the John Snow Memorandum.This work was not in any way directly or indirectly supported, funded, or sponsored by any organisation or entity. NA has experienced prolonged COVID-19 symptoms. AH advises Ligandal (unpaid advisory role), outside the submitted work. FK is collaborating with Pfizer on animal models of SARS-CoV-2, and with the University of Pennsylvania on mRNA vaccines against SARS-CoV-2. FK has also filed IP regarding serological assays and for SARS-CoV-2, which name him as inventor (pending). PK reports personal fees from Kymab, outside the submitted work; PK also has a patent ‘Monoclonal antibodies to treat and prevent infection by SARS-CoV-2 (Kymab)’ pending and is a scientific advisor to the Serology Working Group (Public Heath England), Testing Advisory Group (Department of Health and Social Care) and the Vaccines Task force (Department for Business, Energy and Industrial Strategy). ML has received honoraria from Bristol-Meyers Squibb and Sanofi Pasteur, outside the submitted work. MM is a member of Independent SAGE and Research Director European Observatory on Health Systems and Policies, which manages the COVID Health Systems Response Monitor. DS sits on the Scottish Government COVID-19 Advisory Group, has attended SAGE meetings, and is on the Royal Society DELVE initiative feeding into SAGE. CS reports grants from BMS, Ono-Pharmaceuticals, and Archer Dx (collaboration in minimal residual disease sequencing technologies), outside the submitted work; personal fees from Bristol Myers Squibb, For the John Snow Memorandum see https://www.johnsnowmemo.com/See Online for appendix

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Scientific consensus on the COVID-19 pandemic: we need to act now.

University of Birmingham Research Portal

Scientific consensus on the COVID-19 pandemic:we need to act now

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Eckerle, Isabella Anne

Nouri Zonoz, Ali

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Alwan, Nisreen A.

Goldman, Lynn R.

Hanage, William P.

Hodcroft, Emma B.

Walensky, Rochelle P.

Southampton (e-Prints Soton)

https://purehost.bath.ac.uk/ws/files/212377518/Scientific_consensus_on_the_COVID_19_pandemic_we_need_to_act_now_final_manuscript.pdf

Scientific consensus on the COVID-19 pandemic: we need to act now.

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