Angelis-Dimakis, Athanasios

Bousfield, Thomas W.

Camp, Jason

Nyamini, Simbarashe B.

Pearce, Katharine P. R.

English

Cyrene™ as a bio-alternative dipolar aprotic solvent: a waste minimizing and molar efficient protocol for the synthesis of amides from acid chlorides and primary amines in the bio-available solvent Cyrene™ is disclosed. This protocol removed the use of toxic solvents, such as dimethylformamide and dichloromethane. A simple aqueous work-up procedure for the removal of the high boiling solvent Cyrene™ resulted in up to a 55-fold increase in molar efficiency (Mol E.%) versus standard operating procedures. In order to rapidly compare the molar efficiency of this process against other methodologies an Excel based Mol. E% calculator was developed that automates many of the calculations. An investigation into the hydration of Cyrene™ found that it readily hydrates to form a geminal diol in the presence of water and that this process is exothermic

Bousfield, Thomas

Pearce, Katharine

Nyamini, Simbarashe

Huddersfield Research Portal

Synthesis of amides from acid chlorides and amines in the bio-based solvent Cyrene™

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https://pure.hud.ac.uk/ws/files/17130830/2019_JECamp_Green_Chemistry_revised.pdf

Synthesis of amides from acid chlorides and amines in the bio-based solvent Cyrene™

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Huddersfield Research Portal

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