Colin, Jessie

Gaumer, Sébastien

Guenal, Isabelle

Mignotte, Bernard

HAL Descartes

Mitochondria, Bcl-2 family proteins and apoptosomes: of worms, flies and men

International audienceInitiator caspases are activated within specialized complexes, one of which is the apoptosome. The apoptosome is always constituted by at least an initiator caspase and a caspase activator. Apoptosome activation enables maturation of the associated caspase and constitutes a key step for cell fate. This activating complex is found throughout metazoans but its composition and regulation seem slightly different from one species to another. This review focuses on the composition and activation of the apoptosome in different species and details the role of mitochondrial factors and Bcl 2 family members in this activation

Gaumer, Sebastien

HAL UVSQ

https://hal.archives-ouvertes.fr/hal-00354315

Mitochondria, Bcl-2 family proteins and apoptosomes: of worms, flies and men

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