Austin, Charlotte

Bergeman, Melissa

Davison, William

Farkas, Kata

Kraberger, Simona

Paunil, Emma

Van Doorslaer, Koenraad

Varsani, Arvind

English

Koenraad Van Doorslaer

Simona Kraberger

Charlotte Austin

Kata Farkas

Melissa Bergeman

Emma Paunil

William Davison

Arvind Varsani

Crossref

Journal of General Virology

Fish polyomaviruses belong to two distinct evolutionary lineages

The Polyomaviridae is a diverse family of circular double-stranded DNA viruses. Polyomaviruses have been isolated from a wide array of animal hosts. An understanding of the evolutionary and ecological dynamics of these viruses is essential to understanding the pathogenicity of polyomaviruses. Using a high throughput sequencing approach, we identified a novel polyomavirus in an emerald notothen (Trematomus bernacchii) sampled in the Ross sea (Antarctica), expanding the known number of fish-associated polyomaviruses. Our analysis suggests that polyomaviruses belong to three main evolutionary clades; the first clade is made up of all recognized terrestrial polyomaviruses. The fish-associated polyomaviruses are not monophyletic, and belong to two divergent evolutionary lineages. The fish viruses provide evidence that the evolution of the key viral large T protein involves gain and loss of distinct domains

Bangor University Research Portal

https://research.bangor.ac.uk/portal/files/23157195/567_vir001041.pdf

Fish polyomaviruses belong to two distinct evolutionary lineages

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Bangor University Research Portal