Machine learning technology has the potential to dramatically optimise event generation and simulations. We continue to investigate the use of neural networks to approximate matrix elements for high-multiplicity scattering processes. We focus on the case of loop-induced diphoton production through gluon fusion, and develop a realistic simulation method that can be applied to hadron collider observables. Neural networks are trained using the one-loop amplitudes implemented in the NJet C++ library, and interfaced to the Sherpa Monte Carlo event generator, where we perform a detailed study for 2 → 3 and 2 → 4 scattering problems. We also consider how the trained networks perform when varying the kinematic cuts effecting the phase space and the reliability of the neural network simulations