open access articlePolyether-ether-ketone (PEEK) is an excellent thermoplastic alternative to metallic biomaterials which is used for loadbearing
applications due to its high strength and stiffness, and biocompatibility with no cytotoxic effects. However, a potential clinical
concern is that PEEK alone is not bioactive enough, and thus has limited fixation to bone. To overcome this problem, bioactive
materials and/or porosity are incorporated into PEEK medical devices. The latest developments in these two strategies are presented. in this paper. Bioactive PEEK/hydroxyapatite (HA) prepared by integration of 3D printing and compression molding is presented in this paper. In addition, nozzle and build plate temperatures for 3D printing of porous PEEK were optimized using genetic algorithm (GA) to achieve the highest mechanical strength for load bearing applications such as spinal fusion cages
