Grant support: The Scottish Government's Rural and Environment Science and Analytical Services Division. Declaration of interest: The author declares that there is no conflict of interest.Peer reviewedPublisher PD

Drew, Janice E.

The Open Obesity Journal

English

Intensive research over recent years has provided irrefutable evidence of links between obesity and the risk of
an increasing number of human cancers. The predicted economic burden is causing significant concern. This has
prompted investigation of the underlying mechanisms with a focus on deregulated metabolic pathways. A number of
metabolic processes and associated signalling pathways are associated with the development of obesity. These include a
number of interlinking pathways regulating endocrine, redox, inflammation, immunity and lipogenic processes. The
identification of deregulated metabolic pathways in obesity with promotion of carcinogenesis has targeted research on the
signalling molecules involved. Consequently this mini review is focused on aberrant signalling of deregulated pathways
provoked by diets that lead to obesity and their role in carcinogenesis. Knowledge of the signalling molecules involved
will assist in directing and establishing dietary manipulation strategies to restore metabolic health in obese individuals.
Importantly the identified diversity of signalling pathways linked to obesity related cancers will permit design of more
effective combinatorial and multi-targeted cancer therapies in the future.</jats:p

Janice E. Drew

Crossref

Signalling Pathways Implicated in Obesity Associated Cancers

Grant support: The Scottish Government's Rural and Environment Science and Analytical Services Division. Declaration of interest: The author declares that there is no conflict of interest.Peer reviewe

The Open University

https://aura.abdn.ac.uk/bitstream/2164/4052/1/44TOOBESJ.pdf

Signalling Pathways Implicated in Obesity Associated Cancers

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The Open University