Funding: The APC was funded by the Biotechnology and Biological Sciences Research Council (BB/V016334/1). Acknowledgments: I thank Tatsuya Maeda and Mirai Tanigawa (Hamamatsu University School of Medicine) and Andreas Milias-Argeitis (University of Groningen) for critical reading of the manuscript. I thank Katy Betchetti for English editing.Peer reviewedPublisher PD

Hatakeyama, Riko

Biomolecules

English

Cell growth is dynamically regulated in response to external cues such as nutrient availability, growth factor signals, and stresses. Central to this adaptation process is the Target of Rapamycin Complex 1 (TORC1), an evolutionarily conserved kinase complex that fine-tunes an enormous number of cellular events. How upstream signals are sensed and transmitted to TORC1 has been intensively studied in major model organisms including the budding yeast Saccharomyces&nbsp;cerevisiae. This field recently saw a breakthrough: the identification of yeast phosphatidylInositol(3)-phosphate binding protein 2 (Pib2) protein as a critical regulator of TORC1. Although the study of Pib2 is still in its early days, multiple groups have provided important mechanistic insights on how Pib2 relays nutrient signals to TORC1. There remain, on the other hand, significant gaps in our knowledge and mysteries that warrant further investigations. This is the first dedicated review on Pib2 that summarizes major findings and outstanding questions around this emerging key player in cell growth regulation

Riko Hatakeyama

Multidisciplinary Digital Publishing Institute

Pib2 as an Emerging Master Regulator of Yeast TORC1

Cell growth is dynamically regulated in response to external cues such as nutrient availability, growth factor signals, and stresses. Central to this adaptation process is the Target of Rapamycin Complex 1 (TORC1), an evolutionarily conserved kinase complex that fine-tunes an enormous number of cellular events. How upstream signals are sensed and transmitted to TORC1 has been intensively studied in major model organisms including the budding yeast Saccharomyces cerevisiae. This field recently saw a breakthrough: the identification of yeast phosphatidylInositol(3)-phosphate binding protein 2 (Pib2) protein as a critical regulator of TORC1. Although the study of Pib2 is still in its early days, multiple groups have provided important mechanistic insights on how Pib2 relays nutrient signals to TORC1. There remain, on the other hand, significant gaps in our knowledge and mysteries that warrant further investigations. This is the first dedicated review on Pib2 that summarizes major findings and outstanding questions around this emerging key player in cell growth regulation

Directory of Open Access Journals

Funding: The APC was funded by the Biotechnology and Biological Sciences Research Council (BB/V016334/1). Acknowledgments: I thank Tatsuya Maeda and Mirai Tanigawa (Hamamatsu University School of Medicine) and Andreas Milias-Argeitis (University of Groningen) for critical reading of the manuscript. I thank Katy Betchetti for English editing.Peer reviewe

Aberdeen University Research

https://aura.abdn.ac.uk/bitstream/2164/17369/1/Hatakeyama_etal_MDPI_Pib2_As_An_VoR.pdf

Pib2 as an Emerging Master Regulator of Yeast TORC1

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Multidisciplinary Digital Publishing Institute

Directory of Open Access Journals

Aberdeen University Research