Broche, Lionel

Davies, Gareth Reynold

Kennedy, Brett William Clive

Lurie, David John

Pine, Kerrin

Ross, Peter James

English

Aberdeen University Research

 8th Conference on Field Cycling NMR Relaxometry, Turin, Italy, May 2013 pO11 Field-Cycling Magnetic Resonance Imaging David J. Lurie, Lionel M. Broche, Gareth R. Davies, Brett W.C. Kennedy,  Kerrin J. Pine and P. James Ross Aberdeen Biomedical Imaging Centre, University of Aberdeen, AB25 2ZD, Scotland, UK http://www.ffc-mri.org  The use of Fast Field-Cycling (FFC) in combination with magnetic resonance imaging (MRI) has been increasing gradually in recent years [1].  The first use of FFC-MRI was in conjunction with Proton-Electron Double-Resonance Imaging (PEDRI) to image the distribution of free radicals in biological samples, making use of the Overhauser effect. Field-cycling allows the ESR irradiation to be applied at low field (hence relatively low frequency, and low non-resonant absorption), while NMR signal detection and imaging is carried out at higher field, to preserve SNR [2,3,4].  Relaxometric FFC-MRI aims to obtain spatially-resolved T1-dispersion data, by collecting images at a variety of evolution field strengths [1,5,6,7]. We have demonstrated methods for implementing relaxometry from localised regions defined on a pilot image [8]. We have also shown that FFC relaxometry can detect the formation of cross-linked fibrin protein from fibrinogen in vitro, in a model of the blood clotting process [1,9]. This relies on 14N-1H cross-relaxation phenomena, also known as “quadrupole dips” in the T1-dispersion plot [10]. These reductions in T1, occurring at water proton Larmor frequencies equal to the 14N nuclear quadrupole resonances, reveal information about the concentration and conformation of immobilised protein molecules. In recent work, we have demonstrated the potential of FFC NMR and MRI for the detection of changes in cartilage due to osteoarthritis [11].  FFC-MRI relaxometry is inherently relatively slow, since image data must be collected at a range of evolution magnetic field strengths. We have been investigating a combination of FFC with rapid MR imaging methods such as turbo spin-echo, and have succeeded in speeding up data acquisition significantly, with minimal reduction in image quality or the fidelity of T1-dispersion data [12]. Developments in FFC-MRI have demonstrated this technique’s ability to extract extra information that is not obtainable from conventional, fixed-field techniques. In addition to bio-medical applications, field-cycling magnetic resonance may have applications in the characterisation and monitoring of industrial processes, for example in the preparation of foodstuffs. [1]  Lurie D.J., Aime S., et al., Comptes Rendus Physique 11, 136-148 (2010).† [2]  Lurie D.J., Hutchison J.M.S, et al., J. Magn. Reson. 84, 431-437 (1989). [3]  Lurie D.J., Foster M.A., et al., Phys.Med.Biol. 43, 1877-1886 (1998).† [4]  Lurie D.J., Davies G.R., et al., Magn.Reson.Imaging 23, 175-181 (2005).† [5]  Carlson J.W., Goldhaber D.M., et al., Radiology 184, 635-639 (1992). [6]  Lurie D.J., 1st Symposium on Field-Cycling NMR Relaxometry, Berlin, p5, (1998).† [7]  Ungersma S.E., Matter N.I., et al., Magn.Reson.Med. 55, 1362-1371 (2006). [8]  Pine K.J., Davies G.R. and Lurie D.J., Magn.Reson.Med. 63, 1698–1702 (2010).† [9] Broche L.M., Ismail S. et al., Magn.Reson.Med., 67, 1453–1457 (2012).† [10] Kimmich R., Winter F. et al., J.Magn.Reson., 68, 263-282 (1986). [11] Broche L.M., Ashcroft G.P and Lurie D.J., Magn.Reson.Med. 68, 358-362 (2012).† [12] Ross P.J. et al., Proc. ISMRM 21st Annual Mtng., Salt Lake City, USA, p4217 (2013).†  †These references are available at www.ffc-mri.org/publications.html 

Field-Cycling Magnetic Resonance Imaging

https://aura.abdn.ac.uk/bitstream/2164/10255/1/abstract_Lurie_FC_NMR_Turin_2013.pdf

Field-Cycling Magnetic Resonance Imaging

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