Funding: This research was funded by Wellcome Trust, grant number 216634/Z/19/Z to M.H.M and grant number 222941/Z/21/Z to W.G. Sample collection and W.G, T.K., and M.M. were funded by the South African government through the South African Medical Research Council and the National Research Foundation South African Research Chair Initiative [grant #86949]. The APC was funded by the Wellcome Trust. Author Contributions: Conceptualization, M.H.M., W.G. and M.M.; methodology, M.H.M., W.G., A.P. and M.M.; formal analysis, M.H.M. and W.G.; writing—original draft preparation, M.H.M.; writing—review and editing, W.G., A.P., T.J.K. and M.M.; visualization, M.H.M.; supervision, M.M.; project administration, M.H.M. and M.M.; funding acquisition, M.H.M. and M.M. All authors have read and agreed to the published version of the manuscript.Peer reviewedPublisher PD