Funding This research was funded by Systematic Review Network Center, Iran University of Medical Sciences (Grant Number 97–4–37-13922).Peer reviewedPublisher PD

Baradaran, Hamid Reza

Friberg, Emilie

Gharahjeh, Saeedeh

Khateri, Sorour

Khazaei, Zaher

Moradi, Yousef

Najmi, Zahra

Saed, Lotfolah

Sioofy-Khojine, Amir-Babak

Tehrani, Shahrzad

Varse, Fatemeh

BMC Cancer

Funding This research was funded by Systematic Review Network Center, Iran University of Medical Sciences (Grant Number 97–4–37-13922).Peer reviewe

Aberdeen University Research

English

The effect of diabetes on the risk of endometrial Cancer : an updated a systematic review and meta-analysis

TamPub Julkaisuarkisto - TamPub Institutional Repository

Background: Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabetes and the incidence of this cancer. Thus, the aim of this systematic review and meta-analysis was to more precisely estimate the effect of diabetes on the risk of endometrial cancer incidence. Methods: All original articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to January 2018 without language limitations. Also, logarithm and standard error logarithm relative risk (RR) were used for meta-analysis. Results: A total of 22 cohort and case-control studies were included in this meta-analysis, of which 14 showed statistically significant associations between diabetes and risk of endometrial cancer. Diabetes was associated with increased risk of endometrial cancer (RR = 1.72, 95 CI 1.48-2.01). The summary of RR for all 9 cohort studies was 1.56 (95 CI 1.21-2.01), and it was 1.85 (95 CI 1.53-2.23) for 13 case control studies. The summary of RR in hospital-based studies was higher than other studies. Thirteen of the primary studies-controlled BMI as a confounding variable, and the combined risk of their results was 1.62 (95 CI 1.34-1.97). Conclusions: Diabetes seems to increases the risk of endometrial cancer in women, and this finding can be useful in developing endometrial cancer prevention plans for women having diabetes. Â© 2019 The Author(s)

Saed, L.

Varse, F.

Baradaran, H.R.

Moradi, Y.

Khateri, S.

Friberg, E.

Khazaei, Z.

Gharahjeh, S.

Tehrani, S.

Sioofy-Khojine, A.-B.

Najmi, Z.

eprints Iran University of Medical Sciences

The effect of diabetes on the risk of endometrial Cancer: An updated a systematic review and meta-analysis

Trepo - Institutional Repository of Tampere University

https://trepo.tuni.fi/bitstream/handle/10024/115874/the_effect_of_diabetes_on_the_2019.pdf?sequence=2&isAllowed=y

The effect of diabetes on the risk of endometrial Cancer : an updated a systematic review and meta-analysis

Abstract

Similar works

Full text

Available Versions

Aberdeen University Research

TamPub Julkaisuarkisto - TamPub Institutional Repository

eprints Iran University of Medical Sciences

Trepo - Institutional Repository of Tampere University