The authors are grateful to Francisco Almendros and Ismael Santamaría for help in preparation of the TiO2 substrates. We acknowledge the European Project NERBIOS (NEST/STREP (FP6), 028473-2) for financial support. Maria Canillas acknowledges the JAE-CSIC program of her PhD scholarship. Berta Moreno acknowledges the Fondo Social Europeo and the CSIC for the funding of her JAE Doc contract. Ann Rajnicek acknowledges financial support from The Development Trust at the University of Aberdeen to the Aberdeen Spinal Research Group, including support from the Scottish Rugby Union.Peer reviewedPostprin