Acknowledgements This project was supported by grants of the BMBF (to P.P.) and MOST (to W.L.). We wish to thank W.E.G. Müller (Johannes-Gutenberg-University, Mainz, Germany) for carrying out the cytotoxicity assay. A scholarship (Grant No. 10/6/117) granted and financed by the Egyptian Government (Ministry of High Education) to W.E. is gratefully acknowledged.Peer reviewedPublisher PD

Ebel, Rainer

Ebrahim, Weaam

El Amrani, Mustapha

Kjer, Julia

Lai, Daowan

Lin, Wenhan

Proksch, Peter

Wray, Victor

Marine Drugs

English

PubMed

Chemical investigation of the EtOAc extract of the endophytic fungus &lt;em&gt;Bionectria ochroleuca&lt;/em&gt;, isolated from the inner leaf tissues of the plant &lt;em&gt;Sonneratia caseolaris&lt;/em&gt; (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (&lt;strong&gt;1&lt;/strong&gt; and &lt;strong&gt;2&lt;/strong&gt;) together with three known compounds (&lt;strong&gt;3&lt;/strong&gt;–&lt;strong&gt;5&lt;/strong&gt;). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey’s method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC&lt;sub&gt;50&lt;/sub&gt; values ranging between 0.1 and 6.7 µg/mL

Peter Proksch

Rainer Ebel

Daowan Lai

Wenhan Lin

Weaam Ebrahim

Mustapha El Amrani

Victor Wray

Julia Kjer

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Pullularins E and F, Two New Peptides from the Endophytic Fungus &lt;em&gt;Bionectria ochroleuca&lt;/em&gt; Isolated from the Mangrove Plant&lt;em&gt; Sonneratia caseolaris&lt;/em&gt;

Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3–5). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey’s method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC50 values ranging between 0.1 and 6.7 µg/mL

Multidisciplinary Digital Publishing Institute

Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris

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Acknowledgements This project was supported by grants of the BMBF (to P.P.) and MOST (to W.L.). We wish to thank W.E.G. Müller (Johannes-Gutenberg-University, Mainz, Germany) for carrying out the cytotoxicity assay. A scholarship (Grant No. 10/6/117) granted and financed by the Egyptian Government (Ministry of High Education) to W.E. is gratefully acknowledged.Peer reviewe

Aberdeen University Research

Pullularins E and F, two new peptides from the endophytic fungus Bionectria ochroleuca isolated from the mangrove plant Sonneratia caseolaris

Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3-5). The structures of the new compounds were unambiguously determined on the basis of one-and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey&apos;s method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC50 values ranging between 0.1 and 6.7 mu g/mL.Chemistry, MedicinalSCI(E)0ARTICLE51081-10911

Institutional Repository of Peking University

Pullularins E and F, Two New Peptides from the Endophytic Fungus   Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia   caseolaris

Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3-5). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey's method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC(50) values ranging between 0.1 and 6.7 µg/mL

Helmholtz Zentrum für Infektionsforschung Repository

Pullularins E and F, Two New Peptides from the Endophytic Fungus Bionectria ochroleuca Isolated from the Mangrove Plant Sonneratia caseolaris.

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Pullularins E and F, two new peptides from the endophytic fungus Bionectria ochroleuca isolated from the mangrove plant Sonneratia caseolaris

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