AJ Smith

AM O’Connor

AS Rice

ASC Rice

C Baastrup

DG Altman

DW Shineman

E Sena

ED Rooke

GL Currie

GP Hout van

HB Worp van der

HM Vesterinen

J Higgins

JP Ioannidis

KL Knopp

M Saghaei

MJ Curtis

MR Macleod

N Percie du Sert

NA Andrews

Nature

SC Landis

SE Lazic

ST Bate

TS Reichlin

VC Henderson

W Huang

Crossref

General Principles of Preclinical Study Design

Preclinical studies using animals to study the potential of a therapeutic drug or strategy are important steps before translation to clinical trials. However, evidence has shown that poor quality in the design and conduct of these studies has not only impeded clinical translation but also led to significant waste of valuable research resources. It is clear that experimental biases are related to the poor quality seen with preclinical studies. In this chapter, we will focus on hypothesis testing type of preclinical studies and explain general concepts and principles in relation to the design of in vivo experiments, provide definitions of experimental biases and how to avoid them, and discuss major sources contributing to experimental biases and how to mitigate these sources. We will also explore the differences between confirmatory and exploratory studies, and discuss available guidelines on preclinical studies and how to use them. This chapter, together with relevant information in other chapters in the handbook, provides a powerful tool to enhance scientific rigour for preclinical studies without restricting creativity

Huang, Wenlong

Percie du Sert, Nathalie

Vollert, Jan

Rice, Andrew SC

Spiral - Imperial College Digital Repository

English

General principles of preclinical study design.

du Sert, Nathalie Percie

Rice, Andrew S C

Aberdeen University Research

https://aura.abdn.ac.uk/bitstream/handle/2164/13312/2019_Chapter_.pdf?sequence=1&isAllowed=y

General Principles of Preclinical Study Design

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Spiral - Imperial College Digital Repository

Aberdeen University Research