Acknowledgments We thank all study participants for contributing to the KORA study.Peer reviewedPublisher PD

Aenmacher, Matthias

Brandl, Caroline

Breinlich, Valentin

Enzinger, Sabrina

Grassmann, Felix

Graw, Jochen

Heid, Iris M.

Heier, Margit

Helbig, Horst

Küchenhoff, Helmut

Olden, Matthias

Peters, Annette

Stark, Klaus J.

Weber, Bernhard H.F.

PLoS ONE

English

PubMed

<div><p>Age-related macular degeneration (AMD) is a vision impairing disease of the central retina characterized by early and late forms in individuals older than 50 years of age. However, there is little knowledge to what extent also younger adults are affected. We have thus set out to estimate the prevalence of early AMD features and late AMD in a general adult population by acquiring color fundus images in 2,840 individuals aged 25 to 74 years of the Cooperative Health Research in the Region of Augsburg project (KORA) in South Germany. Among the 2,546 participants with gradable images for each eye, 10.9% (n = 277) had early AMD features (applying the 9-step Age-Related Eye Disease Study Severity Scale), 0.2% (n = 6) had late AMD. Prevalence increased with age, reaching 26.3% for early AMD features and 1.9% for late AMD at the age 70+. However, signs of early AMD were found in subjects as young as 25 years, with the risk for early AMD features increasing linearly by years of age in men, and, less consistent with a linear increase, in women. Risk for early AMD features increased linearly by pack years of smoking in men, not in women, nor was there any association with other lifestyle or metabolic factors. By providing much sought-after prevalence estimates for AMD from Central Europe, our data underscores a substantial proportion of the adult population with signs of early AMD, including individuals younger than 50 years. This supports the notion that early AMD features in the young might be under-acknowledged.</p></div

Caroline Brandl (627466)

Valentin Breinlich (3366932)

Klaus J. Stark (3366923)

Sabrina Enzinger (3366926)

Matthias Aßenmacher (3366929)

Matthias Olden (174839)

Felix Grassmann (162264)

Jochen Graw (47527)

Margit Heier (200535)

Annette Peters (62601)

Horst Helbig (627470)

Helmut Küchenhoff (38752)

Bernhard H. F. Weber (162289)

Iris M. Heid (87553)

FigShare

Features of Age-Related Macular Degeneration in the General Adults and Their Dependency on Age, Sex, and Smoking: Results from the German KORA Study

Age-related macular degeneration (AMD) is a vision impairing disease of the central retina characterized by early and late forms in individuals older than 50 years of age. However, there is little knowledge to what extent also younger adults are affected. We have thus set out to estimate the prevalence of early AMD features and late AMD in a general adult population by acquiring color fundus images in 2,840 individuals aged 25 to 74 years of the Cooperative Health Research in the Region of Augsburg project (KORA) in South Germany. Among the 2,546 participants with gradable images for each eye, 10.9% (n = 277) had early AMD features (applying the 9-step Age-Related Eye Disease Study Severity Scale), 0.2% (n = 6) had late AMD. Prevalence increased with age, reaching 26.3% for early AMD features and 1.9% for late AMD at the age 70+. However, signs of early AMD were found in subjects as young as 25 years, with the risk for early AMD features increasing linearly by years of age in men, and, less consistent with a linear increase, in women. Risk for early AMD features increased linearly by pack years of smoking in men, not in women, nor was there any association with other lifestyle or metabolic factors. By providing much sought-after prevalence estimates for AMD from Central Europe, our data underscores a substantial proportion of the adult population with signs of early AMD, including individuals younger than 50 years. This supports the notion that early AMD features in the young might be under-acknowledged

Aßenmacher, Matthias

Weber, Bernhard H. F.

Universität München: Elektronischen Publikationen

Caroline Brandl

Valentin Breinlich

Klaus J Stark

Sabrina Enzinger

Matthias Aßenmacher

Matthias Olden

Felix Grassmann

Jochen Graw

Margit Heier

Annette Peters

Horst Helbig

Helmut Küchenhoff

Bernhard H F Weber

Iris M Heid

Directory of Open Access Journals

Features of Age-Related Macular Degeneration in the General Adults and Their Dependency on Age, Sex, and Smoking: Results from the German KORA Study.

Open Access LMU

Breinlich, Valentin Andreas

University of Regensburg Publication Server

Age-related macular degeneration (AMD) is a vision impairing disease of the central retina characterized by early and late forms in individuals older than 50 years of age. However, there is little knowledge to what extent also younger adults are affected. We have thus set out to estimate the prevalence of early AMD features and late AMD in a general adult population by acquiring color fundus images in 2,840 individuals aged 25 to 74 years of the Cooperative Health Research in the Region of Augsburg project (KORA) in South Germany. Among the 2,546 participants with gradable images for each eye, 10.9% (n = 277) had early AMD features (applying the 9-step Age-Related Eye Disease Study Severity Scale), 0.2% (n = 6) had late AMD. Prevalence increased with age, reaching 26.3% for early AMD features and 1.9% for late AMD at the age 70+. However, signs of early AMD were found in subjects as young as 25 years, with the risk for early AMD features increasing linearly by years of age in men, and, less consistent with a linear increase, in women. Risk for early AMD features increased linearly by pack years of smoking in men, not in women, nor was there any association with other lifestyle or metabolic factors. By providing much soughtafter prevalence estimates for AMD from Central Europe, our data underscores a substantial proportion of the adult population with signs of early AMD, including individuals younger than 50 years. This supports the notion that early AMD features in the young might be under-acknowledged

Brandl, C.

Breinlich, V.

Stark, K.J.

Enzinger, S.

Aßenmacher, M.

Olden, M.

Grassmann, F.

Graw, J.

Heier, M.

Peters, A.

Helbig, H.

Küchenhoff, H.

Weber, B.H.F.

Heid, I.M.

PuSH

Features of age-related macular degeneration in the general adults and their dependency on age, sex, and smoking: Results from the German KORA study.

Research Archive

Features of age-related macular degeneration in the general adults and their dependency on age, sex, and smoking : Results from the German KORA study

https://epub.uni-regensburg.de/35066/1/journal.pone.0167181.pdf

Features of age-related macular degeneration in the general adults and their dependency on age, sex, and smoking : Results from the German KORA study

Abstract

Similar works

Full text

Available Versions