Acknowledgements: The European Food Safety Authority (EFSA) and authors wish to thank the participants of the break‐out session ‘Advancing risk assessment science – Human health’ at EFSA's third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018) for their active and valuable contributions to the discussion. We also thank Hans Verhagen for carefully proofreading it.Peer reviewedPublisher PD

Bal-Price, Anna

Bois, Frédéric Y.

Castoldi, Anna F.

De Seze, Guilhem

Delclos, K. Barry

Doerge, Daniel R.

Fritsche, Ellen

Halldorsson, Thorhallur

Hougaard Bennekou, Susanne

Kass, George E.N.

Kolossa-Gehring, Marike

Koning, Frits

Lampen, Alfonso

Lanzoni, Anna

Leist, Marcel

Mantus, Ellen

Rousselle, Christophe

Siegrist, Michael

Steinberg, Pablo

Terron, Andrea

Tritscher, Angelika

Van de Water, Bob

Vineis, Paolo

Walker, Nigel

Wallace, Heather

Whelan, Maurice

Younes, Maged

EFSA Journal

Lanzoni, A.

Castoldi, A.F.

Kass, G.E.N.

Terron, A.

Seze, G. de

Bal-Price, A.

Bois, F.Y.

Delclos, K.B.

Doerge, D.R.

Fritsche, E.

Halldorsson, T.

Kolossa-Gehring, M.

Bennekou, S.H.

Koning, F.

Lampen, A.

Leist, M.

Mantus, E.

Rousselle, C.

Siegrist, M.

Steinberg, P.

Tritscher, A.

Water, B. van de

Vineis, P.

Walker, N.

Wallace, H.

Whelan, M.

Younes, M.

NARCIS 

Advancing human health risk assessment

Leiden University Scholary Publications

Publisher's version (útgefin grein)The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal-free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re-engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break-out session ‘Advancing risk assessment science – Human health’ at EFSA's third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018).The European Food Safety Authority (EFSA) and authors wish to thank the
participants of the break-out session ‘Advancing risk assessment science – Human health’ at EFSA’s
third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018) for their
active and valuable contributions to the discussion. We also thank Hans Verhagen for carefully
proofreading it.Peer Reviewe

Castoldi, Anna F

Kass, George EN

Bal‐Price, Anna

Bois, Frédéric Y

Delclos, K Barry

Doerge, Daniel R

Kolossa‐Gehring, Marike

Opin visindi

The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal-free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re-engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break-out session ‘Advancing risk assessment science – Human health’ at EFSA's third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018).</p

Online Research Database In Technology

International audienceThe current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal-free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re-engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break-out session 'Advancing risk assessment science - Human health' at EFSA's third Scientific Conference 'Science, Food and Society' (Parma, Italy, 18-21 September 2018)

Kass, G.E.

de Seze, Guilhem

Bennekou, Susanne Hougaard

Siegrist, Mickael

van de Water, Bob

HAL Descartes

The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal‐free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re‐engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break‐out session ‘Advancing risk assessment science – Human health’ at EFSA's third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018).ISSN:1831-473

Repository for Publications and Research Data

Research Archive

HAL-INERIS

De seze, Guilhem

Hal-Diderot

https://aura.abdn.ac.uk/bitstream/handle/2164/12577/Lanzoni_et_al_2019_EFSA_Journal.pdf?sequence=1&isAllowed=y