The paper describes a study of the hydraulic resistance of the layer of municipal solid waste. Fractal structure – Menger sponge was used as a model for the study of thermal and hydrodynamic processes in solid waste layer. Comparison of experimental and calculated according to pressure drops from the air filtration rate.В работе изложено исследование гидравлического сопротивления слоя твердых бытовых отходов. В качестве модели слоя ТБО для исследования тепловых и гидродинамических процессов использовалась фрактальная структура – губка Менгера. Выполнено сравнение экспериментальной и расчетной зависимости перепада давлений от скорости фильтрации воздуха

Antebi, A.

Bartke, A.

Barzilai, N.

Brown-Borg, H.

Caruso, C.

Curiel, T.

de Cabo, R.

Fontana, L.

Franceschi, C.

Gems, D.

Ingram, D.

Johnson, T.

Kennedy, B.

Kenyon, C.

Klein, S.

Kopchick, J.

Lepperdinger, G.

Longo, V.

Madeo, F.

Mirisola, M.

Mitchell, J.

Passarino, G.

Rudolph, K.

Sedivy, J.

Shadel, G.

Sinclair, D.

Spindler, S.

Suh, Y.

Vijg, J.

Vinciguerra, M.

Aging Cell

PubMed

The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?' was held in Erice, Italy, on October 8-13, 2013, to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, etc.); (ii) drugs that inhibit the growth hormone/IGF-I axis; (iii) drugs that inhibit the mTOR-S6K pathway; or (iv) drugs that activate AMPK or specific sirtuins. These choices were based in part on consistent evidence for the pro-longevity effects and ability of these interventions to prevent or delay multiple age-related diseases and improve healthspan in simple model organisms and rodents and their potential to be safe and effective in extending human healthspan. The authors of this manuscript were speakers and discussants invited to the workshop. The following summary highlights the major points addressed and the conclusions of the meeting

Longo, Valter D

Antebi, Adam

Bartke, Andrzej

Barzilai, Nir

Brown Borg, Holly M

Caruso, Calogero

Curiel, Tyler J

de Cabo, Rafael

Franceschi, Claudio

Gems, David

Ingram, Donald K

Johnson, Thomas E

Kennedy, Brian K

Kenyon, Cynthia

Klein, Samuel

Kopchick, John J

Lepperdinger, Guenter

Madeo, Frank

Mirisola, Mario G

Mitchell, James R

Passarino, Giuseppe

Rudolph, Karl L

Sedivy, John M

Shadel, Gerald S

Sinclair, David A

Spindler, Stephen R

Suh, Yousin

Vijg, Jan

Vinciguerra, Manlio

FONTANA, Luigi

Archivio istituzionale della ricerca - Università di Brescia

Interventions to Slow Aging in Humans: Are We Ready?

The workshop entitled ‘Interventions to Slow Aging in Humans:Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013,to bring together leading experts in the biology and genetics of aging and obtain a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans. There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age. Essential pathways have been identified, and behavioral, dietary, and pharmacologic approaches have emerged. Although many gene targets and drugs were discussed and there was not complete consensus about all interventions, the participants selected a subset of the most promising strategies that could be tested in humans for their effects on healthspan. These were: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, etc.); (ii) drugs that inhibit the growth hormone/IGF-I axis; (iii) drugs that inhibit the mTOR–S6K pathway; or (iv) drugs that activate AMPK or specific sirtuins.These choices were based in part on consistent evidence for the pro-longevity effects and ability of these interventions to prevent or delay multiple age-related diseases and improve healthspan in simple model organisms and rodents and their potential to be safe and effective in extending human healthspan. The authors of this manuscript were speakers and discussants invited to the workshop. The following summary highlights the major points addressed and the conclusions of the meeting.Valter D. Longo, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M. Brown-Borg, Calogero Caruso, Tyler J.Curiel, Rafael de Cabo, Claudio Franceschi, David Gems, Donald K. Ingram, Thomas E. Johnson, Brian K.Kennedy, Cynthia Kenyon, Samuel Klein, John J. Kopchick, Guenter Lepperdinger, Frank Madeo, Mario G. Mirisola, James R. Mitchell, GiuseppePassarino, Karl L. Rudolph, John M. Sedivy, Gerald S.Shadel, David A. Sinclair, Stephen R. Spindler, Yousin Suh, Jan Vijg, Manlio Vinciguerra and Luigi Fontan

Longo, Valter D.

Brown-Borg, Holly M.

Curiel, Tyler J.

De Cabo, Rafael

Ingram, Donald K.

Johnson, Thomas E.

Kennedy, Brian K.

Kopchick, John J.

Mirisola, Mario G.

Mitchell, James R.

Passarino, Guiseppe

Rudolph, Karl L.

Sedivy, John M.

Shadel, Gerald S.

Sinclair, David A.

eplus (Univ. of Salzburg)

Aging Cell / Interventions to slow aging in humans : Are we ready?

ePLUS

Interventions to slow aging in humans : Are we ready?

Publikationsserver der Fachhochschule (FH) Campus Wien

Semenov, A. S.

Dolinin, D. A.

Семенов, А. С.

Долинин, Д. А.

Institutional repository of Ural Federal University named after the first President of Russia B.N.Yeltsin