Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologi

Medeiros, Rodrigo

Portuguese

RCAAP - Repositório Científico de Acesso Aberto de Portugal

A Doença de Alzheimer como um processo neuroinflamatório

Repositório Institucional da UFSC

A century of Alzheimer's disease.

A controlled trial of selegeline, alphatocopherol, or both as treatment for Alzheimer's disease.

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cellto-cell contact.

Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation.

Abnormal phosphorylation of the microtubule-associated protein (tau) in Alzheimer cytoskeletal pathology.

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene.

Accelerated atherosclerosis, aortic aneurysm formation, and ischaemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice.

Activate NF-kappa B or die?

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

Administration of amyloid beta-peptides in the rat medial septum causes memory deficits: reversal by SR 57746A, a non-peptide neurotrophic compound.

Advanced Alzheimer's disease is a risk factor for late-onset seizures.

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.

Alzheimer disease: progress or profit?

Alzheimer's disease skin fibroblasts selectively express a bradykinin signaling pathway mediating tau protein SER phosphorylation.

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.

Alzheimer's disease: the amyloid cascade hypothesis.

Alzheimer's disease.

Amnesic effects in mice of four synthetic peptides homologous to amyloid b protein from patients with Alzheimer's disease.

Amyloid beta-(1-40) stimulates cyclic GMP production via release of kinins inprimary cultured endothelial cells.

Amyloid beta-peptide induces nitric oxide production in rat hippocampus: association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors.

Amyloid betapeptide stimulates nitric oxide production in astrocytes through an NFkappaBdependent mechanism.

Amyloid peptide enhanced bradikininmediated inositol (1,4,5)-triphosphate formation and cytosolic free calcium.

Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci.

An endotoxin-induced serum factor that causes necrosis of tumour.

Animal models of aging: sensory-motor and cognitive function in the aged rat. Em:

Anti-TNFalpha therapies: the next generation.

AP-1 function and regulation.

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Arthritis and anti-inflamatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies.

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies.

ASHKENAZI A

b-Amyloid proteininduced Alzheimer's disease animal model.

B1 receptors as new inflammatory target.

B2 bradykinin receptor immunoreactivity in rat brain.

BACE knockout mice are healthy despite lacking the primary betasecretase activity in brain: implications for Alzheimer's disease therapeutics.

Back to the future with ubiquitin.

Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex.

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

Beta-amyloid inhibition of longterm potentiation is mediated via tumor necrosis factor.

beta-Amyloid-induced neuronal apoptosis requires c-Jun Nterminal kinase activation.

Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide.

Biological significance of nitric oxide-mediated protein modifications.

Bioregulation of kinins: kallikreins, kininogens and kininases.

Blocking NO synthesis: how, where and why? Nat Rev Drug Discov

Bradykinin antagonists: present progress and future prospects.

Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions.

Bradykinin receptor types and B2 subtypes.

Bradykinin signalling to MAP kinase: cell-specific connections versus principle mitogenic pathways.

Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain.

Bradykinininduced amyloid precursor protein secretion: a protein kinase Cindependent mechanism that is not altered in fibroblasts from patients with sporadic Alzheimer's disease.

c-Fos transcriptional activity stimulated by H-Rasactivated protein kinase distinct from JNK and ERK.

Cache County Study Investigators. Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study.

Caffeine reverses agerelated deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors.

Candidate gene for the chromosome 1 familial Alzheimer's disease locus.

Cardiovascular risk factors and Alzheimer’s disease. Current Atherosclerosis Reports

CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis.

Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits. Arterioscler Thromb 14:753–759.

CIECHANOVER A

Clinical diagnosis and course of Alzheimer's disease.

Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under auspices of the department of health and human services task force on Alzheimer’s disease.

Clinical trial of indomethacin in Alzheimer's disease.

Cloning and pharmacological characterization of human bradykinin (BK-2) receptor.

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-.

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.

Competitive antagonists of bradykinin.

Control of vascular cell adhesion molecule-1 gene promoter activity during neural differentiation.

Correlative memory deficits, Ab elevation, and amyloid plaques in transgenic mice.

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain.

Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways.

Cytokine-induced neutrophil chemoattractant mediates neutrophilic alveolitis in rats: association with nuclear factor kappa B activation.

Cytokines in dementias. Curr Drug Targets Inflamm Allergy

Deciphering the molecular basis of memory failure in Alzheimer's disease.

Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha.

Dependence and reversal of nitric oxide production on NF-kappa B in silica and lipopolysaccharide-induced macrophages.

Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system Proc Natl Acad Sci

Differential effects of amyloid peptides b-(1-40) and b-(25-35) injections into the rat nucleus basalis.

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF—B activation prevents cell death.

DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay.

Drug discovery in dementia: the role of rodent models.

Effects of an exogenous b-amyloid peptide on retention for spatial learning.

Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8}bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice.

Effects of the inhibition of p38/ERK MAP kinase on induction of five fos and jun genes by diverse stimuli.

EIB, KAPLAN A

Elevated circulating tumor necrosis factor levels in Alzheimer's disease.

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Enhancement of immunoreactivity for NF-kappa B in the hippocampal formation and cerebral cortex of Alzheimer's disease.

Evolution of neuronal changes in the course of Alzheimer's disease.

Exercise: a behavioral intervention to enhance brain health and plasticity.

Expression cloning of rat B2 bradykinin receptor.

Expression of cloning of a human B1 bradykinin receptor.

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/-mice: isoform-specific effects on neurodegeneration.

GAZIT A

Gene-diet interactions in brain aging and neurodegenerative disorders.

Glial Cells: Mechanical and Functional Supporting Cells of the Nervous System.

GOEDDEL DV (2002) TNF-R1 signaling: a beautiful pathway.

HEYMAN A

Human beta-secretase (BACE) and BACE inhibitors.

Human neuroblastoma cells produce the NF-kB-like HIV-1 transcription activator during differentiation.

Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors.

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.

https://repositorio.ufsc.br/xmlui/bitstream/handle/123456789/90080/247912.pdf?sequence=1&isAllowed=y

A Doença de Alzheimer como um processo neuroinflamatório

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RCAAP - Repositório Científico de Acesso Aberto de Portugal

Repositório Institucional da UFSC