Piperine, a Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus

Abstract

Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type and mutant (CIP(r)-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial efflux pumps